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Article

Placental mTOR links maternal nutrient availability to fetal growth

20 Jan 2009

Abstract excerpt

The mTOR (mammalian target of rapamycin) signalling pathway functions as a nutrient sensor, both in individual cells and, more globally, in organs such as the fat body in Drosophila and the hypothalamus in the rat. The activity of placental amino acid transporters is decreased in IUGR (intrauterine growth restriction), and recent experimental evidence suggests that these changes contribute directly to the...

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PMID: 19143650
DOI: 10.1042/bst0370295

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