Article
Inhibition of HIV-1 replication by balsamin, a ribosome inactivating protein of Momordica balsamina.
PloS one - 1 Jan 2013
Kaur Inderdeep, Puri Munish, Ahmed Zahra, Blanchet Fabien P, Mangeat Bastien, Piguet Vincent
Abstract excerpt
Ribosome-inactivating proteins (RIPs) are endowed with several medicinal properties, including antiviral activity. We demonstrate here that the recently identified type I RIP from Momordica balsamina also possesses antiviral activity, as determined by viral growth curve assays and single-round infection experiments. Importantly, this activity is at play even as doses where the RIP has no cytotoxic effect. In...
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