Article
Transmission of Hypervirulence traits via sexual reproduction within and between lineages of the human fungal pathogen cryptococcus gattii.
PLoS genetics - 1 Jan 2013
Voelz Kerstin, Ma Hansong, Phadke Sujal, Byrnes Edmond J, Zhu Pinkuan, Mueller Olaf, Farrer Rhys A, Henk Daniel A, Lewit Yonathan, Hsueh Yen-Ping, Fisher Matthew C, Idnurm Alexander, Heitman Joseph, May Robin C
Abstract excerpt
Since 1999 a lineage of the pathogen Cryptococcus gattii has been infecting humans and other animals in Canada and the Pacific Northwest of the USA. It is now the largest outbreak of a life-threatening fungal infection in a healthy population in recorded history. The high virulence of outbreak strains is closely linked to the ability of the pathogen to undergo rapid mitochondrial tubularisation and proliferation...
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