MLST and Whole-Genome-Based Population Analysis of Cryptococcus gattii VGIII Links Clinical, Veterinary and Environmental Strains, and Reveals Divergent Serotype Specific Sub-populations and Distant Ancestors.

doi:10.1371/journal.pntd.0004861

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MLST and Whole-Genome-Based Population Analysis of Cryptococcus gattii VGIII Links Clinical, Veterinary and Environmental Strains, and Reveals Divergent Serotype Specific Sub-populations and Distant Ancestors.

PLoS neglected tropical diseases - 1 Aug 2016

Firacative Carolina, Roe Chandler C, Malik Richard, Ferreira-Paim Kennio, Escandón Patricia, Sykes Jane E, Castañón-Olivares Laura Rocío, Contreras-Peres Cudberto, Samayoa Blanca, Sorrell Tania C, Castañeda Elizabeth, Lockhart Shawn R, Engelthaler David M, Meyer Wieland

Abstract excerpt

The emerging pathogen Cryptococcus gattii causes life-threatening disease in immunocompetent and immunocompromised hosts. Of the four major molecular types (VGI-VGIV), the molecular type VGIII has recently emerged as cause of disease in otherwise healthy individuals, prompting a need to investigate its population genetic structure to understand if there are potential genotype-dependent characteristics in its...

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PMID: 27494185
DOI: 10.1371/journal.pntd.0004861
PMCID: PMC4975453

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