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Article

Genetic and anatomical basis of the barrier separating wakefulness and anesthetic-induced unresponsiveness.

PLoS genetics - 1 Jan 2013

Joiner William J, Friedman Eliot B, Hung Hsiao-Tung, Koh Kyunghee, Sowcik Mallory, Sehgal Amita, Kelz Max B

Abstract excerpt

A robust, bistable switch regulates the fluctuations between wakefulness and natural sleep as well as those between wakefulness and anesthetic-induced unresponsiveness. We previously provided experimental evidence for the existence of a behavioral barrier to transitions between these states of arousal, which we call neural inertia. Here we show that neural inertia is controlled by processes that contribute to...

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Identifiers

PMID: 24039590
DOI: 10.1371/journal.pgen.1003605
PMCID: PMC3764144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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