Article
Defective escape behavior in DEAH-box RNA helicase mutants improved by restoring glycine receptor expression.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 Sept 2013
Hirata Hiromi, Ogino Kazutoyo, Yamada Kenta, Leacock Sophie, Harvey Robert J
Abstract excerpt
RNA helicases regulate RNA metabolism, but their substrate specificity and in vivo function remain largely unknown. We isolated spontaneous mutant zebrafish that exhibit an abnormal dorsal bend at the beginning of tactile-evoked escape swimming. Similar behavioral defects were observed in zebrafish embryos treated with strychnine, which blocks glycine receptors (GlyRs), suggesting that the abnormal motor response...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
