Article
New preclinical antimalarial drugs potently inhibit hepatitis C virus genotype 1b RNA replication.
PloS one - 1 Jan 2013
Ueda Youki, Takeda Midori, Mori Kyoko, Dansako Hiromichi, Wakita Takaji, Kim Hye-Sook, Sato Akira, Wataya Yusuke, Ikeda Masanori, Kato Nobuyuki
Abstract excerpt
BACKGROUND: Persistent hepatitis C virus (HCV) infection causes chronic liver diseases and is a global health problem. Although new triple therapy (pegylated-interferon, ribavirin, and telaprevir/boceprevir) has recently been started and is expected to achieve a sustained virologic response of more than 70% in HCV genotype 1 patients, there are several problems to be resolved, including skin rash/ageusia and...
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