Article
Molecular mechanisms of HIV type 1 prophylaxis failure revealed by single-genome sequencing.
The Journal of infectious diseases - 15 Nov 2013
Li Hui, Blair Lily, Chen Yalu, Learn Gerald, Pfafferott Katja, John Mina, Bhattacharya Tanmoy, Hahn Beatrice H, Mallal Simon, Shaw George M, Bar Katharine J
Abstract excerpt
Trials of human immunodeficiency virus type 1 (HIV) pre- and postexposure prophylaxis show promise. Here, we describe a novel strategy for deciphering mechanisms of prophylaxis failure that could improve therapeutic outcomes. A healthcare worker began antiretroviral prophylaxis immediately after a high-risk needlestick injury but nonetheless became viremic 11 weeks later. Single-genome sequencing of plasma viral...
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