Article
Distinction and temporal stability of conformational epitopes on myelin oligodendrocyte glycoprotein recognized by patients with different inflammatory central nervous system diseases.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2013
Mayer Marie C, Breithaupt Constanze, Reindl Markus, Schanda Kathrin, Rostásy Kevin, Berger Thomas, Dale Russell C, Brilot Fabienne, Olsson Tomas, Jenne Dieter, Pröbstel Anne-Katrin, Dornmair Klaus, Wekerle Hartmut, Hohlfeld Reinhard, Banwell Brenda, Bar-Or Amit, Meinl Edgar
Abstract excerpt
Autoantibodies targeting conformationally intact myelin oligodendrocyte glycoprotein (MOG) are found in different inflammatory diseases of the CNS, but their antigenic epitopes have not been mapped. We expressed mutants of MOG on human HeLa cells and analyzed sera from 111 patients (104 children, 7 adults) who recognized cell-bound human MOG, but had different diseases, including acute disseminated...
Topics
- Adolescent
- Adult
- Amino Acid Sequence
- Amino Acid Substitution
- Animals
- Autoantibodies
- Central Nervous System Diseases
- Child
- Child, Preschool