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Article

Single-molecule spectroscopy of cold denaturation and the temperature-induced collapse of unfolded proteins.

Journal of the American Chemical Society - 25 Sept 2013

Aznauryan Mikayel, Nettels Daniel, Holla Andrea, Hofmann Hagen, Schuler Benjamin

Abstract excerpt

Recent Förster resonance energy transfer (FRET) experiments show that heat-unfolded states of proteins become more compact with increasing temperature. At the same time, NMR results indicate that cold-denatured proteins are more expanded than heat-denatured proteins. To clarify the connection between these observations, we investigated the unfolded state of yeast frataxin, whose cold denaturation occurs at...

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Identifiers

PMID: 24010673
DOI: 10.1021/ja407009w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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