Article
Mononuclear cells from a rare blood donor, after freezing under good manufacturing practice conditions, generate red blood cells that recapitulate the rare blood phenotype.
Transfusion - 1 Apr 2014
Masiello Francesca, Tirelli Valentina, Sanchez Massimo, van den Akker Emile, Gabriella Girelli, Marconi Maurizio, Villa Maria Antonietta, Rebulla Paolo, Hashmi Ghazala, Whitsett Carolyn, Migliaccio Anna Rita
Abstract excerpt
BACKGROUND: Cultured red blood cells (cRBCs) from cord blood (CB) have been proposed as transfusion products. Whether buffy coats discarded from blood donations (adult blood [AB]) may be used to generate cRBCs for transfusion has not been investigated. STUDY DESIGN AND METHODS: Erythroid progenitor cell content and numbers and blood group antigen profiles of erythroblasts (ERYs) and cRBCs generated in human...
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