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Article

Hypoxia, hypoxia-inducible factors and fibrogenesis in chronic liver diseases.

1 Jan 2014

Abstract excerpt

Fibrogenic progression of chronic liver diseases (CLDs) towards the end-point of cirrhosis is currently regarded, whatever the aetiology, as a dynamic and highly integrated cellular response to chronic liver injury. Liver fibrogenesis (i.e., the process) is sustained by hepatic populations of highly proliferative, pro-fibrogenic and contractile myofibroblast-like cells (MFs) that mainly originate from hepatic...

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PMID: 23996844
DOI: 10.14670/hh-29.33

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