Article
Distinct global shifts in genomic binding profiles of limb malformation-associated HOXD13 mutations.
Genome research - 1 Dec 2013
Ibrahim Daniel M, Hansen Peter, Rödelsperger Christian, Stiege Asita C, Doelken Sandra C, Horn Denise, Jäger Marten, Janetzki Catrin, Krawitz Peter, Leschik Gundula, Wagner Florian, Scheuer Till, Schmidt-von Kegler Mareen, Seemann Petra, Timmermann Bernd, Robinson Peter N, Mundlos Stefan, Hecht Jochen
Abstract excerpt
Gene regulation by transcription factors (TFs) determines developmental programs and cell identity. Consequently, mutations in TFs can lead to dramatic phenotypes in humans by disrupting gene regulation. To date, the molecular mechanisms that actually cause these phenotypes have been difficult to address experimentally. ChIP-seq, which couples chromatin immunoprecipitation with high-throughput sequencing, allows...
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