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Article

Timing of pathogen adaptation to a multicomponent treatment.

PloS one - 1 Jan 2013

Bourget Romain, Chaumont Loïc, Sapoukhina Natalia

Abstract excerpt

The sustainable use of multicomponent treatments such as combination therapies, combination vaccines/chemicals, and plants carrying multigenic resistance requires an understanding of how their population-wide deployment affects the speed of the pathogen adaptation. Here, we develop a stochastic model describing the emergence of a mutant pathogen and its dynamics in a heterogeneous host population split into...

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Identifiers

PMID: 23991006
DOI: 10.1371/journal.pone.0071926
PMCID: PMC3749216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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