Article
A novel tetranucleotide repeat polymorphism within KCNQ1OT1 confers risk for hepatocellular carcinoma.
DNA and cell biology - 1 Nov 2013
Wan Jiao, Huang Moli, Zhao Hua, Wang Chaoqun, Zhao Xiankun, Jiang Xinghong, Bian Shizhong, He Yan, Gao Yuzhen
Abstract excerpt
KCNQ1 overlapping transcript 1 (KCNQ1OT1), a long noncoding RNA responsible for silencing a cluster of genes in cis, has been shown to be involved in multiple cancers. However, much remains unclear of how KCNQ1OT1 contributes to carcinogenesis. By thoroughly analyzing 510 hepatocellular carcinoma (HCC) cases and 1014 healthy controls in a Chinese population, we identified a novel short tandem repeat (STR)...
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