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Glyphosate and AMPA inhibit cancer cell growth through inhibiting intracellular glycine synthesis

1 Jul 2013

Abstract excerpt

Glycine is a nonessential amino acid that is reversibly converted from serine intracellularly by serine hydroxymethyltransferase. Glyphosate and its degradation product, aminomethylphosphonic acid (AMPA), are analogs to glycine, thus they may inhibit serine hydroxymethyltransferase to decrease intracellular glycine synthesis. In this study, we found that glyphosate and AMPA inhibited cell growth in eight human...

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PMID: 23983455
DOI: 10.2147/dddt.s49197

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