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Article

Complement modulates the cutaneous microbiome and inflammatory milieu

26 Aug 2013

Abstract excerpt

The skin is colonized by a plethora of microbes that include commensals and potential pathogens, but it is currently unknown how cutaneous host immune mechanisms influence the composition, diversity, and quantity of the skin microbiota. Here we reveal an interactive role for complement in cutaneous host-microbiome interactions. Inhibiting signaling of the complement component C5a receptor (C5aR) altered the...

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PMID: 23980152
DOI: 10.1073/pnas.1307855110

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