Article
Influence of microsatellite instability and KRAS and BRAF mutations on lymph node harvest in stage I-III colon cancers.
Molecular medicine (Cambridge, Mass.) - 10 Sept 2013
Berg Marianne, Guriby Marianne, Nordgård Oddmund, Nedrebø Bjørn S, Ahlquist Terje C, Smaaland Rune, Oltedal Satu, Søreide Jon Arne, Kørner Hartwig, Lothe Ragnhild A, Søreide Kjetil
Abstract excerpt
Lymph node (LN) harvest is influenced by several factors, including tumor genetics. Microsatellite instability (MSI) is associated with improved node harvest, but the association to other genetic factors is largely unknown. Research methods included a prospective series of stage I-III colon cancer patients undergoing ex vivo sentinel-node sampling. The presence of MSI, KRAS mutations in codons 12 and 13, and BRAF...
Topics
- Adult
- Aged
- Aged, 80 and over
- Colonic Neoplasms
- Female
- Humans
- Lymph Nodes
- Male
- Microsatellite Instability
- Middle Aged
- Mutation