Article
Overexpression of the toll-like receptor (TLR) signaling adaptor MYD88, but lack of genetic mutation, in myelodysplastic syndromes.
PloS one - 1 Jan 2013
Dimicoli Sophie, Wei Yue, Bueso-Ramos Carlos, Yang Hui, Dinardo Courtney, Jia Yu, Zheng Hong, Fang Zhihong, Nguyen Martin, Pierce Sherry, Chen Rui, Wang Hui, Wu Chenghua, Garcia-Manero Guillermo
Abstract excerpt
MYD88 is a key mediator of Toll-like receptor innate immunity signaling. Oncogenically active MYD88 mutations have recently been reported in lymphoid malignancies, but has not been described in MDS. To characterize MYD88 in MDS, we sequenced the coding region of the MYD88 gene in 40 MDS patients....
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