Article
Breed-linked polymorphisms of porcine toll-like receptor 2 (TLR2) and TLR4 and the primary investigation on their relationship with prevention against Mycoplasma pneumoniae and bacterial LPS challenge.
Immunogenetics - 1 Nov 2013
Fang Xiaomin, Liu Xiao, Meng Cui, Fu Yanfeng, Wang Xuemin, Li Bixia, Tu Feng, Zhao Fang, Ren Shouwen
Abstract excerpt
Toll-like receptors (TLRs) play a crucial role in innate immunity, serving as pattern-recognition receptors and the first barrier in host defense against microbial infections. Genetic variations of TLR2 and TLR4 are closely associated with a variety of infectious diseases, particularly lung diseases. In this study, we detected six and four single nucleotide polymorphisms (SNPs) in the coding sequences of porcine...
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