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Telomere length dynamics in human memory T cells specific for viruses causing acute or latent infections

26 Aug 2013

Abstract excerpt

BACKGROUND: Declining telomere length (TL) is associated with T cell senescence. While TL in naïve and memory T cells declines with increasing age, there is limited data on TL dynamics in virus-specific memory CD4+ T cells in healthy adults. We combined BrdU-labeling of virus-stimulated T cells followed with flow cytometry-fluorescent in situ hybridization for TL determination. We analyzed TL in T cells specific...

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PMID: 23971624
DOI: 10.1186/1742-4933-10-37

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