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Article

H3K27 demethylase, JMJD3, regulates fragmentation of spermatogonial cysts.

PloS one - 1 Jan 2013

Iwamori Naoki, Iwamori Tokuko, Matzuk Martin M

Abstract excerpt

The spermatogonial stem cell (SSC) compartment is maintained by self-renewal of stem cells as well as fragmentation of differentiating spermatogonia through abscission of intercellular bridges in a random and stochastic manner. The molecular mechanisms that regulate this reversible developmental lineage remain to be elucidated. Here, we show that histone H3K27 demethylase, JMJD3 (KDM6B), regulates the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23967333
DOI: 10.1371/journal.pone.0072689
PMCID: PMC3744460

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