Article
Strengths and limitations of microarray-based phenotype prediction: lessons learned from the IMPROVER Diagnostic Signature Challenge.
Bioinformatics (Oxford, England) - 15 Nov 2013
Tarca Adi L, Lauria Mario, Unger Michael, Bilal Erhan, Boue Stephanie, Kumar Dey Kushal, Hoeng Julia, Koeppl Heinz, Martin Florian, Meyer Pablo, Nandy Preetam, Norel Raquel, Peitsch Manuel, Rice Jeremy J, Romero Roberto, Stolovitzky Gustavo, Talikka Marja, Xiang Yang, Zechner Christoph
Abstract excerpt
MOTIVATION: After more than a decade since microarrays were used to predict phenotype of biological samples, real-life applications for disease screening and identification of patients who would best benefit from treatment are still emerging. The interest of the scientific community in identifying best approaches to develop such prediction models was reaffirmed in a competition style international collaboration...
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