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Article

The ATP costs and time required to degrade ubiquitinated proteins by the 26 S proteasome.

The Journal of biological chemistry - 4 Oct 2013

Peth Andreas, Nathan James A, Goldberg Alfred L

Abstract excerpt

The degradation of ubiquitinated proteins by 26 S proteasomes requires ATP hydrolysis. To investigate if the six proteasomal ATPases function independently or in a cyclic manner, as proposed recently, we used yeast mutants that prevent ATP binding to Rpt3, Rpt5, or Rpt6. Although proteasomes cont...

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Identifiers

PMID: 23965995
DOI: 10.1074/jbc.M113.482570
PMCID: PMC3790020

Genes

DHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23965995-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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