Article
Demethylation pathways in caffeine metabolism as indicators of variability in 1,1,1-trichloroethane oxidation in man.
Pharmacology & toxicology - 1 Jul 1990
Berode M, Boillat M A, Guillemin M P, Wu M M, Savolainen H
Abstract excerpt
Twenty volunteers were exposed to 191 +/- 7 p.p.m. 1,1,1-trichloroethane or 50 +/- 2 p.p.m. perchloroethylene vapour for 6 hr. They were then evaluated for their rate of caffeine metabolism, mephenytoin hydroxylation and debrisoquine hydroxylation. Seven subjects were identified as 'fast acetylators' of caffeine and one person as a slow metabolizer of debrisoquine. The "slow acetylators" exposed to...
Topics
- Adult
- Alcohol Drinking
- Caffeine
- Creatinine
- Dealkylation
- Humans
- Hydrocarbons, Chlorinated
- Male
- Oxidation-Reduction
- Phenotype
- Regression Analysis
- Smoking