Article
Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A.
Proceedings of the National Academy of Sciences of the United States of America - 3 Sept 2013
Jiang Daohua, Zhao Yan, Wang Xianping, Fan Junping, Heng Jie, Liu Xuehui, Feng Wei, Kang Xusheng, Huang Bo, Liu Jianfeng, Zhang Xuejun Cai
Abstract excerpt
The major facilitator superfamily (MFS) is the largest family of secondary active transporters and is present in all life kingdoms. Detailed structural basis of the substrate transport and energy-coupling mechanisms of these proteins remain to be elucidated. YajR is a putative proton-driven MFS transporter found in many Gram-negative bacteria. Here we report the crystal structure of Escherichia coli YajR at 3.15...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.