Article
Canine homolog of the T-box transcription factor T; failure of the protein to bind to its DNA target leads to a short-tail phenotype.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Mar 2001
Haworth K, Putt W, Cattanach B, Breen M, Binns M, Lingaas F, Edwards Y H
Abstract excerpt
Domestic dog breeds show a wide variety of morphologies and offer excellent opportunities to study the molecular genetics of phenotypic traits. We are interested in exploring this potential and have begun by investigating the genetic basis of a short-tail trait. Our focus has been on the T gene, which encodes a T-box transcription factor important for normal posterior mesoderm development. Haploinsufficiency of T...
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