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Article

Association of Genes in the <scp>NF</scp>‐κB Pathway with Antibody‐Positive Primary Sjögren's Syndrome

15 Aug 2013

Abstract excerpt

Primary Sjögren's syndrome (SS) is a systemic autoimmune inflammatory disease characterized by focal lymphocytic infiltrates in the lachrymal and salivary glands and autoantibodies against the SSA/Ro and SSB/La antigens. Experimental studies have shown an activation of NF-κB in primary SS. NF-κB activation results in inflammation and autoimmunity and is regulated by inhibitory and activating proteins. Genetic...

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PMID: 23944604
DOI: 10.1111/sji.12101

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