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Evolution of caspase-mediated cell death and differentiation: twins separated at birth

24 Mar 2017

Abstract excerpt

The phenotypic and biochemical similarities between caspase-mediated apoptosis and cellular differentiation are striking. They include such diverse phenomenon as mitochondrial membrane perturbations, cytoskeletal rearrangements and DNA fragmentation. The parallels between the two disparate processes suggest some common ancestry and highlight the paradoxical nature of the death-centric view of caspases. That is,...

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PMID: 28338655
DOI: 10.1038/cdd.2017.37

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