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Article

NVP-LDE225, a potent and selective SMOOTHENED antagonist reduces melanoma growth in vitro and in vivo.

PloS one - 1 Jan 2013

Jalili Ahmad, Mertz Kirsten D, Romanov Julia, Wagner Christine, Kalthoff Frank, Stuetz Anton, Pathria Gaurav, Gschaider Melanie, Stingl Georg, Wagner Stephan N

Abstract excerpt

Melanoma is one of the most aggressive cancers and its incidence is increasing worldwide. So far there are no curable therapies especially after metastasis. Due to frequent mutations in members of the mitogen-activated protein kinase (MAPK) signaling pathway, this pathway is constitutively active in melanoma. It has been shown that the SONIC HEDGEHOG (SHH)-GLI and MAPK signaling pathway regulate cell growth in...

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Identifiers

PMID: 23935925
DOI: 10.1371/journal.pone.0069064
PMCID: PMC3728309

Genes

BRAF
SHH
GLI1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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