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Article

Defective decidualization during and after severe preeclampsia reveals a possible maternal contribution to the etiology

18 Sept 2017

Abstract excerpt

In preeclampsia (PE), cytotrophoblast (CTB) invasion of the uterus and spiral arteries is often shallow. Thus, the placenta's role has been a focus. In this study, we tested the hypothesis that decidual defects are an important determinant of the placental phenotype. We isolated human endometrial stromal cells from nonpregnant donors with a previous pregnancy that was complicated by severe PE (sPE). Compared with...

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PMID: 28923940
DOI: 10.1073/pnas.1706546114

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