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Article

MicroRNA‐106a induces multidrug resistance in gastric cancer by targeting RUNX3

7 Aug 2013

Abstract excerpt

Multidrug resistance (MDR) is the main barrier to the success of chemotherapy for gastric cancer (GC). miR-106a, which is highly expressed in GC, influences a variety of aspects of GC. However, the function of miR-106a in MDR of GC still remains unclear. In the present study, we found that miR-106a is elevated in MDR cell lines. miR-106a promotes chemo-resistance of GC cells, accelerates ADR efflux, and...

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PMID: 23932924
DOI: 10.1016/j.febslet.2013.06.058

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