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Associations with growth factor genes (FGF1, FGF2, PDGFB, FGFR2, NRG2, EGF, ERBB2) with breast cancer risk and survival: the Breast Cancer Health Disparities Study.

Breast cancer research and treatment - 1 Aug 2013

Slattery Martha L, John Esther M, Stern Mariana C, Herrick Jennifer, Lundgreen Abbie, Giuliano Anna R, Hines Lisa, Baumgartner Kathy B, Torres-Mejia Gabriela, Wolff Roger K

Abstract excerpt

Growth factors (GF) stimulate cell proliferation through binding to cell membrane receptors and are thought to be involved in cancer risk and survival. We examined how genetic variation in epidermal growth factor (EGF), neuregulin 2 (NRG2), ERBB2 (HER2/neu), fibroblast growth factors 1 and 2 (FGF1 and FGF2) and its receptor 2 (FGFR2), and platelet-derived growth factor B (PDGFB) independently and collectively...

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Source

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Identifiers

PMID: 23912956
DOI: 10.1007/s10549-013-2644-5
PMCID: PMC3860319

Genes

ERBB2
FGF1
FGFR2
FGF2
NRG2
PDGFB
EGF
EGFR

Provenance

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