Article
Molecular cloning, primary structure and expression of the human X linked A1S9 gene cDNA which complements the ts A1S9 mouse L cell defect in DNA replication.
The EMBO journal - 1 Sept 1990
Zacksenhaus E, Sheinin R
Abstract excerpt
The temperature-sensitive ts A1S9 mutation of mouse L cells was previously shown to affect nuclear DNA replication and to be complemented by active and inactive human X chromosomes in human-ts A1S9 somatic cell hybrids. We report the isolation of cDNA clones which correct the ts A1S9 lesion, usin...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Cycle
- Cell Line
- Cloning, Molecular
- DNA
- DNA Replication
- Gene Library
- Genes
- Humans
- L Cells
- Mice
- Molecular Sequence Data
- Mutation
- Nucleic Acid Hybridization
- Restriction Mapping
- X Chromosome