Article
Common cancers--genetics, origin, prevention, screening: Parts I and II.
Disease-a-month : DM - 1 Oct 1997
Schifeling D J, Horton J, Tafelski T J
Abstract excerpt
Carcinogenesis is a stepwise process that occurs through mutations of cancer-related genes. Five or more genes must be mutated before malignant transformation occurs in most adult cancers; in some childhood cancers as few as two mutated genes may be sufficient. A rare inherited mutation of a critical gene may predestine cancer to occur in one or more sites. This germline mutation is present in virtually every...
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