Article
Specific mutations in H5N1 mainly impact the magnitude and velocity of the host response in mice.
BMC systems biology - 29 Jul 2013
Tchitchek Nicolas, Eisfeld Amie J, Tisoncik-Go Jennifer, Josset Laurence, Gralinski Lisa E, Bécavin Christophe, Tilton Susan C, Webb-Robertson Bobbie-Jo, Ferris Martin T, Totura Allison L, Li Chengjun, Neumann Gabriele, Metz Thomas O, Smith Richard D, Waters Katrina M, Baric Ralph, Kawaoka Yoshihiro, Katze Michael G
Abstract excerpt
BACKGROUND: Influenza infection causes respiratory disease that can lead to death. The complex interplay between virus-encoded and host-specific pathogenicity regulators - and the relative contributions of each toward viral pathogenicity - is not well-understood. RESULTS: By analyzing a collection of lung samples from mice infected by A/Vietnam/1203/2004 (H5N1; VN1203), we characterized a signature of transcripts...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.