A chemokine gene expression signature derived from meta-analysis predicts the pathogenicity of viral respiratory infections

Abstract excerpt

BACKGROUND: During respiratory viral infections host injury occurs due in part to inappropriate host responses. In this study we sought to uncover the host transcriptional responses underlying differences between high- and low-pathogenic infections. RESULTS: From a compendium of 12 studies that included responses to influenza A subtype H5N1, reconstructed 1918 influenza A virus, and SARS coronavirus, we used...

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