Article
TusA (YhhP) and IscS are required for molybdenum cofactor-dependent base-analog detoxification.
MicrobiologyOpen - 1 Oct 2013
Kozmin Stanislav G, Stepchenkova Elena I, Schaaper Roel M
Abstract excerpt
Lack of molybdenum cofactor (Moco) in Escherichia coli leads to hypersensitivity to the mutagenic and toxic effects of N-hydroxylated base analogs, such as 6-N-hydroxylaminopurine (HAP). This phenotype is due to the loss of two Moco-dependent activities, YcbX and YiiM, that are capable of reducing HAP to adenine. Here, we describe two novel HAP-sensitive mutants containing a defect in iscS or tusA (yhhP) gene....
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