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Article

The iscS gene deficiency affects the expression of pyrimidine metabolism genes.

Biochemical and biophysical research communications - 1 Aug 2008

Mihara Hisaaki, Hidese Ryota, Yamane Masahiro, Kurihara Tatsuo, Esaki Nobuyoshi

Abstract excerpt

Inactivation of iscS encoding cysteine desulfurase results in a slow growth phenotype associated with the deficiency of iron-sulfur clusters, thiamine, NAD, and tRNA thionucleosides in Escherichia coli. However, the other roles of iscSin vivo are unknown. By using differential screening strategies, we identified 2 pyrimidine salvage enzymes, namely, uridine phosphorylase and cytidine deaminase, which were...

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PMID: 18482579
DOI: 10.1016/j.bbrc.2008.05.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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