Article
CymR, the master regulator of cysteine metabolism in Staphylococcus aureus , controls host sulphur source utilization and plays a role in biofilm formation
8 Jun 2009
Abstract excerpt
We have characterized the master regulator of cysteine metabolism, CymR, in Staphylococcus aureus. CymR repressed the transcription of genes involved in pathways leading to cysteine formation. Eight direct DNA targets were identified using gel-shift or footprinting experiments. Comparative transcriptome analysis and in vitro studies indicated that CysM, the OAS-thiol-lyase, was also implicated in this regulatory...
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