Article
Potential synergy between SNP and CpG-A or IL-1β in regulating transcriptional activity of IL-20 promoter.
The Journal of investigative dermatology - 1 Feb 2014
Wang Lanqi, Li Kejia, Xu Qiannan, Chen Xiaoying, Xue Feng, Shi Ruofei, Zheng Jie
Abstract excerpt
Psoriasis is a multifactorial cutaneous disorder that in many aspects is influenced by both genetic and environmental elements. IL-20, a member of IL-10 family, is found to be involved in the development of psoriasis. In our previous study, a single-nucleotide polymorphism (SNP) of IL-20-1723CG (rs1713239) was found to be associated with psoriasis progression, especially in those induced by upper respiratory...
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