Article
Abca3 haploinsufficiency is a risk factor for lung injury induced by hyperoxia or mechanical ventilation in a murine model.
Pediatric research - 1 Oct 2013
Herber-Jonat Susanne, Mittal Rashmi, Huppmann Marceline, Hammel Markus, Liebisch Gerhard, Yildirim Ali Önder, Eickelberg Oliver, Schmitz Gerd, Hrabé de Angelis Martin, Flemmer Andreas W, Holzinger Andreas
Abstract excerpt
BACKGROUND: Heterozygous ATP-binding-cassette subfamily A member 3 (ABCA3) mutations are associated with neonatal respiratory complications. In an adult murine model, we investigated whether Abca3 haploinsufficiency is a predisposing factor for lung injury induced by hyperoxia or mechanical ventilation. METHODS: Abca3 haploinsufficient (Abca3(+/-)) and wild-type (WT) mice were prospectively randomized to 25 min...
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