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Article

Genotype-specific QT correction for heart rate and the risk of life-threatening cardiac events in adolescents with congenital long-QT syndrome.

Heart rhythm - 1 Aug 2011

Barsheshet Alon, Peterson Derick R, Moss Arthur J, Schwartz Peter J, Kaufman Elizabeth S, McNitt Scott, Polonsky Slava, Buber Jonathan, Zareba Wojciech, Robinson Jennifer L, Ackerman Michael J, Benhorin Jesaia, Towbin Jeffrey A, Vincent G Michael, Zhang Li, Goldenberg Ilan

Abstract excerpt

BACKGROUND: A prolonged QT interval corrected for heart rate (QTc) is a major risk factor in patients with long QT syndrome (LQTS). However, heart rate-related risk in this genetic disorder differs among genotypes. OBJECTIVE: This study hypothesized that risk assessment in LQTS patients should incorporate genotype-specific QT correction for heart rate. METHODS: The independent contribution of 4 repolarization...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21397043
DOI: 10.1016/j.hrthm.2011.03.009
PMCID: PMC3641882

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