Beta-blocker efficacy in high-risk patients with the congenital long-QT syndrome types 1 and 2: implications for patient management.

Abstract excerpt

BACKGROUND: Beta-blockers are the mainstay therapy in patients with the congenital long-QT syndrome (LQTS) types 1 and 2. However, limited data exist regarding the efficacy and limitations of this form of medical management within high-risk subsets of these populations. METHODS AND RESULTS: Multivariate analysis was carried out to identify age-related gender- and genotype-specific risk factors for cardiac events...

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