Molecular evolution in court: analysis of a large hepatitis C virus outbreak from an evolving source

Abstract excerpt

BACKGROUND: Molecular phylogenetic analyses are used increasingly in the epidemiological investigation of outbreaks and transmission cases involving rapidly evolving RNA viruses. Here, we present the results of such an analysis that contributed to the conviction of an anesthetist as being responsible for the infection of 275 of his patients with hepatitis C virus. RESULTS: We obtained sequences of the NS5B and...

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