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Article

Novel modulating effects of PKC family genes on the relationship between serum vitamin D and relapse in multiple sclerosis.

Journal of neurology, neurosurgery, and psychiatry - 1 Apr 2014

Lin Rui, Taylor Bruce V, Simpson Steve, Charlesworth Jac, Ponsonby Anne-Louise, Pittas Fotini, Dwyer Terence, van der Mei Ingrid A F

Abstract excerpt

BACKGROUND: The interplay between genes and environmental factors on multiple sclerosis (MS) clinical course has been little studied. METHODS: We conducted a prospective cohort study of 141 participants with relapsing-remitting MS (RRMS) and genotype data followed from 2002 to 2005 and examined genes in the vitamin D metabolism and vitamin D receptor (VDR)/retinoid X receptor (RXR) transcription factor formation...

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Topics

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Share to Gene-Environment Interaction
Share to Multiple Sclerosis, Relapsing-Remitting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Kinase C

Share to Receptors, Calcitriol

Share to Recurrence

Share to Retinoid X Receptors

Share to Signal Transduction

Share to Vitamin D

Source

Identifiers

PMID: 23868949
DOI: 10.1136/jnnp-2013-305245

Genes

PRKCB
PRKCH
PRKCZ
VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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