High population frequencies of APOL1 risk variants are associated with increased prevalence of non-diabetic chronic kidney disease in the Igbo people from south-eastern Nigeria.

doi:10.1159/000353223

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High population frequencies of APOL1 risk variants are associated with increased prevalence of non-diabetic chronic kidney disease in the Igbo people from south-eastern Nigeria.

Nephron. Clinical practice - 1 Jan 2013

Ulasi Ifeoma I, Tzur Shay, Wasser Walter G, Shemer Revital, Kruzel Etty, Feigin Elena, Ijoma Chinwuba K, Onodugo Obinna D, Okoye Julius U, Arodiwe Ejikeme B, Ifebunandu Ngozi A, Chukwuka Chinwe J, Onyedum Cajetan C, Ijoma Uchenna N, Nna Emmanuel, Onuigbo Macaulay, Rosset Saharon, Skorecki Karl

Abstract excerpt

BACKGROUND: Continental Africa is facing an epidemic of chronic kidney disease (CKD). APOL1 risk variants have been shown to be strongly associated with an increased risk for non-diabetic kidney disease including HIV nephropathy, primary non-monogenic focal and segmental glomerulosclerosis, and hypertension-attributed nephropathy among African ancestry populations in the USA. The world's highest frequencies of...

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PMID: 23860441
DOI: 10.1159/000353223

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APOL1

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