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Regulatory and Exhausted T Cell Responses to AAV Capsid

21 Mar 2017

Abstract excerpt

Recombinant adeno-associated viruses (AAVs) are quickly becoming the preferred viral vector for viral gene delivery for the treatment of a wide variety of genetic disorders. However, since their use in a clinical trial targeting hemophilia B patients 10 years ago, immune responses to the AAV capsid appear to have hampered some of the early clinical gene transfer efficacy. Indeed, AAV-based gene transfer has been...

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PMID: 28323492
DOI: 10.1089/hum.2017.022

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