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Article

Effect of mutations at position E138 in HIV-1 reverse transcriptase on phenotypic susceptibility and virologic response to etravirine.

Journal of acquired immune deficiency syndromes (1999) - 1 Sept 2011

Tambuyzer Lotke, Nijs Steven, Daems Bjorn, Picchio Gaston, Vingerhoets Johan

Abstract excerpt

The contribution of E138 mutations to etravirine resistance was investigated. Amino acids at position E138 after failure with etravirine in DUET were A (n = 1), G (n = 5), K (n = 3), P (n = 1), Q (n = 5), and V (n = 2). At baseline, only E138A and Q were found at 3.0% and 2.5%, respectively. Virologic response (less than 50 copies/mL) was observed in six of 12 and eight of 10 patients with E138A and E138Q,...

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Identifiers

PMID: 21637112
DOI: 10.1097/QAI.0b013e3182237f74

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