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Article

Ethnic Variation in Inflammatory Profile in Tuberculosis

4 Jul 2013

Abstract excerpt

Distinct phylogenetic lineages of Mycobacterium tuberculosis (MTB) cause disease in patients of particular genetic ancestry, and elicit different patterns of cytokine and chemokine secretion when cultured with human macrophages in vitro. Circulating and antigen-stimulated concentrations of these inflammatory mediators might therefore be expected to vary significantly between tuberculosis patients of different...

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PMID: 23853590
DOI: 10.1371/journal.ppat.1003468

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